Inhibition of Progesterone Action by a Factor in Human Follicular Fluid
- 1 June 1993
- journal article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 25 (06) , 298-300
- https://doi.org/10.1055/s-2007-1002103
Abstract
A factor was found in human follicular fluid that blocked progesterone-stimulated net uptake of 45Ca2+ in human sperm and progesterone-induced maturation of Xenopus oocyte. The factor was partially purified by ultrafiltration through PM-10 membrane and gel filtration on Sephadex G-25 column. The active fraction is effective at a concentration of 200 micrograms/ml. The present findings suggest that hFF factor may regulate the metabolism of progesterone sensitive cells.Keywords
This publication has 0 references indexed in Scilit: