A model of malignant urinary bladder tumor in rabbits.

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Abstract
A malignant urinary bladder tumor in rabbits was produced by transplanting tumor cells. Each of 51 male mixed-bred rabbits received 0.3 ml [rabbit] V2 carcinoma cells suspension. The transplantation was done after laparotomy via injection into the bladder wall. Within 2 wk malignant tumors were observed in the bladder. Without any manipulation to the mucosa, all tumors were led to exulceration in the bladder lumen. The incidence of malignant tumor reached 96%. Metastases in these animals were seen in the lungs and para-aortic lymph nodes. This malignant tumor model seems especially suitable for the study of new methods of transurethral treatment of bladder cancer.