HISTOCHEMICAL STUDY OF ‘ALKALINE’ PHOSPHATASE THE KIDNEY OF THE CASTRATED MOUSE AFTER STIMULATION WITH VARIOUS ANDROGENS

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Abstract
The distribution of the "alkaline" phosphatase of the kidney of the mouse was studied after treatment with 18 different steroids many of which were studied at several dose levels. There was a progressive decrease in the enzyme from the distal end of the proximal convoluted tubule toward the glomerulus with a slight increase in concn. at the glomerular end. These changes paralleled the increase in kidney size under steroid stimulation so that at maximum stimulation the kidney showed varying degrees of depletion of the enzyme in its nephrons.