Effect of cimetidine on the human lower oesophageal sphincter.
Open Access
- 1 February 1977
- Vol. 18 (2) , 99-104
- https://doi.org/10.1136/gut.18.2.99
Abstract
Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrations during cimetidine infusion were measured by radioimmunoassay and showed no significant variation. In a further series of experiments, the response of the lower oesophageal sphincter to intravenous bolus injection of pentagastrin was measured before and during cimetidine infusion. Cimetidine infusion had no significant effect on the sphincter response to pentagastrin.This publication has 28 references indexed in Scilit:
- Inhibition of food-stimulated gastric acid secretion by cimetidine.Gut, 1976
- Relationship of serum gastrin response to lower oesophageal sphincter pressure.Gut, 1976
- Pharmacological evaluation of cimetidine, a new histamine H2‐receptor antagonist, in healthy man.British Journal of Clinical Pharmacology, 1975
- 24-HOUR CONTROL OF INTRAGASTRIC ACIDITY BY CIMETIDINE IN DUODENAL-ULCER PATIENTSThe Lancet, 1975
- Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.Gut, 1975
- Relationship between changes in plasma gastrin and lower oesophageal sphincter pressure after mealsBritish Journal of Surgery, 1975
- Stimulation of the incompetent lower esophageal sphincterDigestive Diseases and Sciences, 1973
- Metoclopramide in gastrooesophageal refluxGut, 1973
- Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretinJournal of Clinical Investigation, 1971
- Action of gastrin on the lower oesophageal sphincter in manGut, 1969