Insect Moulting Hormones: The Synthesis of Possible Ecdysone Precursors for Metabolic Studies
- 1 January 1974
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 27 (5) , 1087-1095
- https://doi.org/10.1071/ch9741087
Abstract
The possible biological precursors of ecdysones, 3β-hydroxy-5β-cholest-7-en-6-one (2) and 3β,14α-dihydroxy-5β-cholest-7-en-6-one (3), are prepared from 7-dehydrocholesterol through their 5α-epimers.The corresponding 3α-[3H] derivatives of high specific activity are prepared in a similar way via 5α-cholest-7-ene-3β,6α-diol[3α-3H] 6-acetate which is obtained by reducing the corresponding 3-keto derivative with sodium borotritide.Keywords
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