The Occurrence of Psammoma Bodies in Papillary Adenocarcinoma of the Lung

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Abstract
In a series of 56 consecutive necropsies of patients with primary adenocarcinoma of the lung, nine of the lesions contained psammoma bodies. Three similar cases not from this series are included in the study. The 12 adenocarcinomas contained papillary formations, with the psammoma bodies easily recognizable within the glands and papillary processes of the primary tumor and, in several instances, in their metastatic foci. The psammoma bodies were laminated and nonlaminated types and contained various amounts of mucopolysaccharides, iron, and calcium. The differentiation of these tumors from other papillary adenocarcinomas with psammoma bodies, especially of the thyroid gland, is important because of the prognostic and therapeutic implications. In two recent surgical cases, metastatic papillary adenocarcinomas with psammoma bodies were found in cervical and mediastinal lymph nodes with the primary sites of the tumors in the lungs.

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