RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture
Open Access
- 1 November 2006
- journal article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 155 (5) , 645-653
- https://doi.org/10.1530/eje.1.02289
Abstract
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.Keywords
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