A General Approach to Aza‐Heterocycles by Means of Domino Sequences Driven by Hydroformylation
- 1 December 2008
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 14 (35) , 10938-10948
- https://doi.org/10.1002/chem.200801795
Abstract
The development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient N‐acyliminium that can be trapped by various nucleophiles to give several aza‐heterocylic scaffolds in a diastereoselective manner.Keywords
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