AGRANULOCYTOSIS AND HEPATOCELLULAR JAUNDICE

18 October 1947

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 135 (7) , 422-425
https://doi.org/10.1001/jama.1947.02890070024006

Abstract

The increasing incidence of toxic reactions following thiouracil therapy is well known today. As a substitute for this drug Astwood and Vanderlaan¹recommended propylthiouracil. There were no significant side effects encountered in their series of 100 cases. Reveno²in his observations on 54 patients found no evidence of toxic effect on the blood or blood-forming tissues. The only side effects encountered by the aforementioned authors were pruritus, urticaria and drug fever. Bartels³has given propylthiouracil to 450 patients at the Lahey Clinic with a toxicity incidence of 2 per cent. There has been 1 case of agranulocytosis, 5 cases exhibiting depressed leukocyte counts and 1 case revealing a typical fever response. In the reports received thus far, Hardy⁴knows of 1 case of agranulocytosis (Bartels') and states that a number of patients showed a drop in the leukocyte count, which soon rose despite the continuation of

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