A MOLECULAR-MODEL FOR THE REGULATION OF SYNAPSE EFFICACY AT THE POSTSYNAPTIC LEVEL
- 1 January 1982
- journal article
- research article
- Vol. 295 (12) , 665-670
Abstract
The regulation of efficacy of a chemical synapse at the postsynaptic level is discussed in terms of the reversible allosteric transitions of the receptor for the neurotransmitter. The proposed model accounts for the regulation of a synapse by its own state of activity and by that of neighboring synapses on the same neuron. The model predicts persisting changes of efficacy in the time-scale of seconds-minutes compatible with short-term memory processes following, in particular, the scheme of classical conditioning.This publication has 6 references indexed in Scilit:
- Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitizationBiochemistry, 1982
- Desensitization at the frog neuromuscular junction: a biphasic processThe Journal of Physiology, 1982
- Retrograde Inhibition of Transmitter Release by ATPJournal of Neurochemistry, 1980
- Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorataEuropean Journal of Biochemistry, 1979
- A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plateThe Journal of Physiology, 1957
- A further study of the statistical composition of the end‐plate potentialThe Journal of Physiology, 1955