Synthesis and Biological Activity of Cyclohexenyl Nucleosides.cis-5-(9H-Purin-9-yl)-3-cyclohexenyl Carbinols and Their 8-Azapurinyl Analogs
- 1 November 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 14 (9-10) , 2061-2077
- https://doi.org/10.1080/15257779508010724
Abstract
5-Azido-3-cyclohexenecarboxylic acid was reduced to an aminocyclohexenyl-carbinol which was coupled with either 5-amino-4,6-dichloropyrimidine or 2-amino-4,6-dichloropyrimidine, giving 5-pyrimidinyl-3-cyclohexencarbinols. Condensation with triethylorthoformate or nitrous acid formed the purine and 8-azapurine ring systems, respectively. Anti-HIV-1 and cytotoxicity testing results are also described.Keywords
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