Comparison of (β-adrenoceptor populations in cat and guinea-pig left atria

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Abstract
The subtypes of β-adrenoceptor present in left atrial preparations from the guinea-pig and cat have been assessed using both responses obtained in organ bath experiments and radioligand binding studies. From the positive inotropic responses to procaterol, the pKB values for practolol using a variety of agonists, and from displacement of [125 I]cyanopindolol from left atrial membrane homogenates by the selective β1 and β2-adrenoceptor antagonists L643, 717-01J10 and ICI 118, 551, it was concluded that guinea-pig left atria possess only β1-adrenoceptors, whilst cat left atria possess both β1- and β2-adrenoceptor subtypes.