ASSOCIATION OF MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) WITH HLA-B-8 AND B-13

  • 1 January 1981
    • journal article
    • research article
    • Vol. 15  (4) , 172-174
Abstract
HLA antigens of 45 children with idiopathic nephrotic syndrome were typed for 26 phenotypic specificities. A significant association of MCNS [minimal change nephrotic syndrome] with HLA-B-8 and B-13 was found. There was also a significantly increased frequency of the antigen combination HLA-A-1/B-8 (most presumably the haplotype). The association with HLA-B-8 provides further evidence of an important role of immune mechanisms in the pathogenesis of MCNS.