Effects of cadmium and zinc on spontaneous and antibody‐dependent cell‐mediated cytotoxicity

1 January 1986

journal article
research article
Published by Taylor & Francis in Journal of Toxicology and Environmental Health

Vol. 18 (2) , 293-300
https://doi.org/10.1080/15287398609530869

Abstract

Various metals, in particular, cadmium, have been found to interfere with a variety of aspects of immune function. Recently, spontaneous cell‐mediated cytotoxicity (SCMC) and antibody‐dependent cell‐mediated cytotoxicity (ADCC) have been widely investigated due to their purported role in immune surveillance. Thus, the effects of cadmium on these two processes were examined. The effects of zinc and the combination of these two metals were also investigated. Both cadmium and zinc were found to inhibit SCMC and ADCC in a dose‐dependent manner. In combination, the effects of the metal were generally additive.

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