PEG-Linked luminescent platinum(ii) complex as aqueous polymeric molecular light switch for protein binding reactionsElectronic supplementary information (ESI) available: general experimental procedure, synthesis and characterization of 1 and 2, titration experiments and urea unfolding of BSA. See http://www.rsc.org/suppdata/cc/b2/b207395a/
- 2 October 2002
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 21,p. 2556-2557
- https://doi.org/10.1039/b207395a
Abstract
Attachment of poly(ethylene glycol) (PEG) to [Pt(4-HOPh-C⁁N⁁N)Cl] via covalent etheric bonds yields the luminescent polymer PEG-[Pt] (2), the photoluminescence of which is enhanced in hydrophobic regions of protein molecules (binding constant up to 104 M−1) in aqueous solution; complex 2 can function as a luminescent probe for protein denaturation due to urea unfolding reaction.Keywords
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