In Vitro Activity of the Ketolide ABT-773

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Abstract
The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC 90 ] was ≤0.06 μg/ml), including all strains that were macrolide resistant but clindamycin susceptible. Streptococcus pneumoniae and other streptococci were inhibited by low concentrations of ABT-773, and that included most erythromycin-resistant strains. Against Haemophilus influenzae , ABT-773 and azithromycin were similar in their antibacterial potency (MIC 90 , 4.0 and 2.0 μg/ml, respectively).