Apolipoprotein E receptors: linking brain development and alzheimer's disease
- 1 October 2000
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 1 (1) , 51-58
- https://doi.org/10.1038/35036221
Abstract
Alzheimer's disease is a debilitating neurodegenerative disorder that afflicts an increasing part of our ageing population. An isoform of apolipoprotein E, a protein that mediates the transport of lipids and cholesterol in the circulatory system, predisposes carriers of this allele to the common late-onset form of the disease. How this protein is related to a neurodegenerative disorder is an enigma. Mounting evidence indicates that apolipoprotein E receptors, which are abundantly expressed in most neurons in the central nervous system, also fulfil critical functions during brain development and may profoundly influence the pathogenesis of Alzheimer's disease.Keywords
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