Biotin and glucose metabolism

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Abstract
Biotin enhances liver glucokinase in the diabetic rat. Experiments using inhibitors of protein and RNA synthesis suggest that this is mediated through de novo protein synthesis. Biotin treatment also increases the activities of other key glycolytic kinases, phosphofructokinase and pyruvate kinase, but has no effect on a bifunctional enzyme like phosphohexose isomerase.

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