Probenecid Binding by Renal Cortical Slices And Homogenates.

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Abstract
The uptake of probenecid by kidney cortex slices was examined over a 100-fold concentration range. An analysis of these data indicated tissue binding to be an important mechanism in the slice uptake process. For example, the steady-state accumulation conformed to a modified "Scatchard plot". Two populations of binding sites exist. Probenecid was bound to kidney cortex homogenates, but not by liver or renal medulla homogenates, an observation in keeping with slice data reported previously.