Block of Thalamic T-Type Ca2+ Channels by Ethosuximide Is Not the Whole Story
- 1 March 2002
- journal article
- Published by SAGE Publications in Epilepsy Currents
- Vol. 2 (2) , 53-56
- https://doi.org/10.1046/j.1535-7597.2002.00024.x
Abstract
On the basis of more than a decade of studies on the cellular effects of ethosuximide, currently, the most prudent view is that together with a block of the low threshold, T-type Ca(2)(+) current, a reduction both of the noninactivating Na(+) current, and the Ca(2)(+)-activated K(+) current in thalamic and cortical neurones contribute to the overall therapeutic action of this antiabsence medicine.Keywords
This publication has 27 references indexed in Scilit:
- Lack of the Burst Firing of Thalamocortical Relay Neurons and Resistance to Absence Seizures in Mice Lacking α1G T-Type Ca2+ ChannelsNeuron, 2001
- Regulation of the calcium channel α1G subunit by divalent cations and organic blockersNeuropharmacology, 2000
- Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsyThe Journal of Physiology, 1998
- Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.The Journal of Physiology, 1995
- Basic mechanisms of generalized absence seizuresAnnals of Neurology, 1995
- Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neuronsNeuroscience, 1992
- Development of calcium current subtypes in isolated rat hippocampal pyramidal cells.The Journal of Physiology, 1991
- Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reductionBritish Journal of Pharmacology, 1990
- Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neuronsAnnals of Neurology, 1989
- Specific petit mal anticonvulsants reduce calcium currents in thalamic neuronsNeuroscience Letters, 1989