Increased Brain Uptake of Copper and Zinc in Mice Caused by Diethyldithiocarbamate
- 1 July 1979
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 45 (1) , 41-44
- https://doi.org/10.1111/j.1600-0773.1979.tb02358.x
Abstract
Mice given 64CuCl2 and 65ZnCl2 (10 μmol/kg) were treated with sodium diethyldithiocarbamate (0.5 mmol/kg). The treatment increased the brain level of radioactive copper five-fold and that of radioactive zinc three-fold. Such redistribution of metal ions may be explained from the formation of lipophilic metal chelates. The increased brain levels may involve neurotoxic effects.Keywords
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