Tn5030: A Conjugative Transposon Conferring Clindamycin Resistance in Bacteroides Species
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 12 (Supplement) , S235-S242
- https://doi.org/10.1093/clinids/12.supplement_2.s235
Abstract
Several examples of conjugal transfer of antibiotic resistance determinants in the absence of plasmid DNA have been described in gram-positive species. Previous work had suggested that transfer of clindamycin resistance among the gram-negative anaerobic Bacteroides species might occur by a similar mechanism. Wereport here the characterization of Tn5030, a 45-kb ± 5-kb chromosomal, mobile genetic element devoid of the detectable terminal repeats typically associated with gram-negative transposons. Tn5030 transfers clindamycin resistance (ermFU) and sequences homologous to tetF in the absence of detectable plasmid DNA. This element represents a novel mechanism of genetic exchange among gram-negative organisms.Keywords
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