Cryosurgical treatment of dysplasia and carcinoma in situ of the cervix uteri

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Abstract
Fifty-nine patients (age range 18-40 yr, mean 28 yr with dysplasia or carcinoma in situ of the cervix uteri were treated with cryosurgery. Healing occurred in 54 patients (91.6%) after 1 treatment (double freeze technique) and in 2 patients after refreezing. No early or late complications occurred during a follow-up period of 7-37 mo. Five patients with carcinoma in situ were followed immunologically with determinations of serum TPA (tissue polypeptide antigen), which can be employed as a parameter of malignancy. In all instances the initially elevated TPA normalized after cryosurgical treatment. Cryosurgery is a simple, painless and safe treatment method in ectocervically localized carcinoma in situ and dyplasia particularly suited for out-patient use.

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