The metabolism in vitro of tissue slices from rats given triethyltin compounds

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Abstract
The effect of triethyltin on the respiratory activity of rat-tissue slices was examined. Brain slices are the most strongly inhibited. Brain slices prepared from rats given triethyltin show a lowered metabolism in vitro. Liver and kidney slices do not differ from controls. Data on triethyltin distribution in the rats show that the highest concentrations are in erythrocytes and liver. In vitro, brain, liver and kidney slices take up triethyltin from the medium to produce a concentration greater in the tissues than in the medium. When the amount of triethyltin found in whole brain in vivo and in slices in vitro is expressed as the concentration in the tissue fluid, there is a close correlation between the concentrations which are effective in vivo and in vitro.