The Tryptophan Load and Pyridoxine Deficiency

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Abstract
Urinary excretions of xanthurenlc acid, hydroxykynurenine, and hydroxyanthranilic acid have been compared after administration to normal subjects of 2 g and 5 g of L-tryptophan before and after supplementation with large doses of pyridoxine. The results are interpreted as favoring the recommendation that a 2-g dose of tryptophan be accepted as the standard load in the tryptophan load test for pyridoxine deficiency. Measurement of 24-hr, urinary excretion of xanthurenic acid or hydroxykynurenine by specific column chromatographic technics is suggested. Tolerance limits for excretion of these metabolites by normal subjects are reported.

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