Radiotoxicity of 75 Se and 35 S: Theory and Application to a Cellular Model

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Abstract
The radiotoxicity of the Auger electron emitter, 75Se, relative to the negatron emitter, 35S was investigated using 75Se-selenomethionine and 35S-methionine. These analog compounds were mainly incorporated into the cytoplasmic proteins of dividing cells. Their uptake was linear with increasing extracellular radioactivity. Both radionuclides were equally effective in killing V79 Chinese hamster lung fibroblasts by theoretical dose estimates. Auger electron-emitting radionuclides in the cytoplasma generaly contribute minimally to radiation-induced cell death.