N-Methyl, 5-Methyl Histamine Evokes a Higher Maximal Rate of Gastric Acid Secretion than Histamine
- 1 November 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 156 (2) , 296-298
- https://doi.org/10.3181/00379727-156-39924
Abstract
In cats with gastric fistulas, the histamine H2 receptor agonist N-methyl, 5-methyl histamine gave a higher maximal rate of acid secretion than histamine. Histamine plus a histamine H1 receptor antagonist [pyrilamine] also gave a higher maximal rate of acid secretion than histamine alone. These findings are compatible with the hypothesis that histamine acts on H1 receptors to inhibit acid secretion.This publication has 1 reference indexed in Scilit:
- THE ROLE OF HISTAMINE IN GASTRIC HYDROCHLORIC ACID SECRETIONAnnals of the New York Academy of Sciences, 1962