VANCOMYCIN PHARMACOKINETICS IN PREMATURE-INFANTS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 5  (1) , 17-22
Abstract
Vancomycin [effective against Staphylococcus aureus and S. epidermidis] pharmacokinetics were studied in 9 premature infants. Infants weighing < 1000 g had significantly larger volumes of drug distribution and consequently longer drug half-lives than larger premature infants, regardless of postconceptual or actual age. These differences alter the vancomycin dosing recommendations in these 2 groups of premature infants. Initial dosage regimens consisting of a loading dose of vancomycin of 25 mg/kg followed by doses of 15 mg/kg every 12 h for infants weighing < 1000 g are recommended. Infants weighing > 1000 g should receive 10 mg/kg every 12 h, with a loading dose of 12.5 mg/kg. Serum vancomycin concentration should be monitored for final optimization of therapy.