MECHANISM OF ACTION OF STAPHYLOCOCCAL ALPHA-HEMOLYSIN II
- 1 December 1963
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 86 (6) , 1189-1195
- https://doi.org/10.1128/jb.86.6.1189-1195.1963
Abstract
Marucci, Americo A. (Upstate Medical Center, Syracuse, N.Y.). Mechanism of action of staphylococcal alpha-hemolysin. II. Analysis of the kinetic curve and inhibition by specific antibody. J. Bacteriol. 86:1189–1195. 1963.—At least two steps are necessary before the rabbit erythrocyte is lysed by staphylococcal alpha-hemolysin. The first step involves the reaction of alpha-hemolysin with the red cell. The second step, leading to the release of hemoglobin, is an intrinsic reaction of the damaged red cell and takes place without further participation of hemolysin. The speed of this intrinsic reaction is temperature-dependent. Erythrocytes taken from the same rabbit do not vary in their susceptibility to the alpha-hemolysin. From the results of the experiments described herein, a preliminary hypothesis on the mechanism of action of staphylococcal alpha-hemolysin is given.This publication has 6 references indexed in Scilit:
- MECHANISM OF ACTION OF STAPHYLOCOCCAL ALPHA-HEMOLYSIN IJournal of Bacteriology, 1963
- INTRODUCTION: IMMUNOCHEMISTRY OF ENZYMESAnnals of the New York Academy of Sciences, 1963
- Isolation and Composition of Staphylococcal Alpha ToxinJournal of General Microbiology, 1963
- Some characteristics of staphylococcus alpha hæmolysinThe Journal of Pathology and Bacteriology, 1962
- STUDIES WITH STAPHYLOCOCCAL TOXINS: V. POSSIBLE IDENTIFICATION OF ALPHA HEMOLYSIN WITH A PROTEOLYTIC ENZYMECanadian Journal of Microbiology, 1960
- STAPHYLOCOCCUS PYOGENES AND ITS RELATION TO DISEASEThe Lancet Healthy Longevity, 1959