Concomitant administration of MK-801 and desipramine enhances extracellular concentration of dopamine in the rat prefrontal cortex

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Abstract
The interaction between the antidepressant drug desipramine and the non-competitive NMDA receptor antagonist MK-801 was investigated at the level of dopamine release in the rat prefrontal cortex. Peripheral administration of MK-801 (0.2 mg kg-1) or desipramine (10 mg kg-1) evoked weak enhancement of the extracellular dopamine concentration in the rat PFC. Desipramine and MK-801 given jointly in doses which by themselves evoked a mild alteration of dopamine outflow (10 mg and 0.2 mg kg-1 respectively) produced pronounced enhancement of the extracellular concentration of dopamine in the rat prefrontal cortex. It is suggested that the non-competitive NMDA receptor antagonist may enhance the efficacy of classical antidepressant drugs.

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