Morphine Tolerance and Dependence Induced by Intraventricular Injection

1 October 1971

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 174 (4004) , 74-76
https://doi.org/10.1126/science.174.4004.74

Abstract

Injection of small quantities of morphine into the cerebral ventricular system of awake, relatively unrestrained, monkeys depressed or abolished operant food-reinforced lever pressing. After repeated injections progressively higher doses of morphine were needed to depress responding. Also, dependence could be demonstrated in these animals by precipitating specific abstinence signs with an antagonist.

Keywords

This publication has 3 references indexed in Scilit:

On the central sites for the antinociceptive action of morphine and fentanyl
Neuropharmacology, 1970
Reinforcement Properties of Morphine, Cocaine, and SPA as a Function of Unit Dose
International Journal of the Addictions, 1968
Pharmacological Aspects of Drug Dependence
Published by Elsevier ,1964