In Utero Central Nervous System Damage in Pyruvate Dehydrogenase Deficiency
- 1 September 1988
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 45 (9) , 987-989
- https://doi.org/10.1001/archneur.1988.00520330073012
Abstract
• Pyruvate dehydrogenase deficiency is among the most common causes of congenital lactic acidosis. We describe siblings with congenital lactic acidosis due to a deficiency of pyruvate dehydrogenase complex. The findings of computed tomography and pathologic studies suggest that central nervous system damage had occurred in utero. These observations have implications for treatment and outcome in patients with enzymatic defects causing congenital lactic acidosis.This publication has 8 references indexed in Scilit:
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