THE ROLE OF CHLORIDES IN ALKALOSIS

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Abstract
The term "alkalosis" was used originally by Fischler1in 1911 with reference to the toxemia of animals with Eck fistulas because the disturbance was attributed to a disproportion between the acid and base in the body. Alkalosis has since assumed increasing significance in relation to various experimental and clinical problems. It was first reported as a complication of the Sippy treatment of peptic ulcer by Grant2in 1922, although Sippy himself had previously recognized its occurrence.3Its manifestations have now become familiar to most clinicians as a result of the detailed accounts of Hardt and Rivers,4Ellis,5Gatewood and his associates6and others.7Despite the fact that the original Sippy powders were mixtures of sodium bicarbonate and calcium carbonate, the systemic effects of alkali administration were attributed entirely to the highly soluble sodium bicarbonate, and the influence of calcium carbonate on the electrolyte

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