The Metabolism of Chlorpromazine and Promethazine to give new ‘Pink Spots’ Proposals for the Mechanisms Involved
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (7) , 449-452
- https://doi.org/10.3109/00498257509056115
Abstract
Mechanisms are proposed for the removal, during metabolism, of the aminoalkyl side chain from chlorpromazine and promethazine and for the subsequent formation of nitroxides, N-hydroperoxides, N-oxyhydroperoxides and hydroxylamines from the phenothiazine nuclei.Keywords
This publication has 4 references indexed in Scilit:
- Metabolic incorporation of oxygen into primary and secondary aliphatic amines and the consequences in carbon-nitrogen bond cleavageJournal of Pharmacy and Pharmacology, 1975
- The Metabolism of Chlorpromazine and Promethazine to give New ‘Pink Spots’Xenobiotica, 1975
- The mechanism of metabolic N-oxidation of phentermine and chlorphentermine to their hydroxylamino- and nitroso-compoundsJournal of Pharmacy and Pharmacology, 1974
- Chlorpromazine ‘hydroxylamines' in red blood cells as major metabolites of chlorpromazine in manJournal of Pharmacy and Pharmacology, 1973