Vitamin B6 reduces cortisone‐induced cleft palate in the mouse

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Abstract
Administration of Vitamin B6 during gestation to mice on a Vitamin B6‐containing diet resulted in a substantial reduction in cortisone‐induced cleft palate. Mice maintained on a Vitamin B6‐deficient diet demonstrated an increase in the frequency of cortisone‐induced cleft palate; this effect was prevented by administration of Vitamin B6. Vitamin B6 inhibited the specific binding of a labeled glucocorticoid to cytosolic receptors from cultured palatal mesenchyme cells. These results indicate that Vitamin B6 reduces the incidence of cortisone‐induced cleft palate by altering the binding of glucocorticoids to their cytoplasmic receptors and subsequently nuclear acceptors.