Comparative Study of the Bronchospasmolytic Effect of Fenoterol (0.2 mg) and Salbutamol (0.4 mg) as Powder inhalations in 20 Patients with Reversible Bronchial Obstruction

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Abstract
In a double-blind crossover study, the effects of fenoterol powder inhaled from capsules (0.2 mg) and the powder inhaler with salbutamol capsules (0.4 mg) were compared. A single dose of each was administered on 2 subsequent days in random order. The effects on lung function tests results were followed from 15-360 min after administration. Apart from the overall comparison, special attention was paid to the beginning and the end of the test periods. Statistically significant differences were found only in a few parameters and showed a trend for fenoterol to have a somewhat longer effect and for salbutamol to have a faster onset of effect. The differences between the effects of the 2 drugs were clinically not relevant. Blood pressure and heart rate were unaffected by either treatment.

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