Total synthesis of 26-hydroxyepothilone B and related analogues
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 24,p. 2343-2344
- https://doi.org/10.1039/a705845d
Abstract
A series of 26-substituted epothilones B (3, 22, 23a–n and 24a–h,j–l,o) have been constructed by total synthesis involving a selective Wittig olefination, an aldol reaction and a macrolactonization as key steps.Keywords
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