Chemical structure and inhalation toxicity of lipopolysaccharides from bacteria on cotton

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Abstract
Lipopolysaccharides from different bacteria isolated from cotton were purified and chemically analyzed. Their pulmonary toxicity to animals [guinea pigs] was tested in inhalation tests. Lipopolysaccharides from Agrobacterium and Xanthomonas differed from the others in that they contained no heptose and no non-hydroxylated fatty acids with a chain length of 12, 14 or 16 C atoms. Lipopolysaccharides from Pseudomonas putida, Enterobacter agglomerans [Erwinia herbicola] and Klebsiella oxytoca caused an influx of polymorphonuclear leukocytes into the airways. Lipopolysaccharides from Agrobacterium sp. and Xanthomonas sinensis caused no significant invasion. The data point to substances in both the lipid A part and the core part of the lipopolysaccharides being responsible for the capacity to induce leukocyte invasion into the airways.

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