Time and dose dependency of bone-sarcomas in patients injected with radium-224
- 31 May 1988
- journal article
- research article
- Published by Springer Nature in Radiation and Environmental Biophysics
- Vol. 27 (2) , 103-114
- https://doi.org/10.1007/bf01214600
Abstract
The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity.This publication has 4 references indexed in Scilit:
- Temporal distributions of risk for radiation-induced cancersJournal of Chronic Diseases, 1987
- Effects on Populations of Exposure to Low Levels of Ionizing Radiation, 1980Published by The National Academies Press ,1980
- Skeletal Effects Following 224Ra Injections Into HumansHealth Physics, 1978
- The rates of growth of skeletal sarcomasCancer, 1965