INHIBITION OF CELL-DIVISION BY INTERFERON - CHANGES IN CELL-CYCLE CHARACTERISTICS AND IN MORPHOLOGY OF EHRLICH ASCITES TUMOR-CELLS IN CULTURE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 48  (APR) , 259-279
Abstract
Proliferation of Ehrlich [mouse] ascites tumor cells in culture is strongly inhibited by mouse interferon. This effect is accompanied by increases in cell volume and protein, RNA and DNA content, and by acquisition of a more fibroblastic morphology of the cells. The slower rate of cell division is characterized by prolongation of the S phase of the cell cycle by 100%, the G2 phase by 44% and mitosis by 150%. The G1 phase is slightly shortened. There is a marked rise in the proportion of multinucleate cells. Some of these changes may be due to interferon-induced elevation of cAMP content in these cells.