Physostigmine in choreiform movement disorders
- 1 January 1974
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 24 (1) , 28
- https://doi.org/10.1212/wnl.24.1.28
Abstract
Dopaminergic-cholinergic balance is a clinically observable phenomenon in Parkinson's disease and in L-dopa-induced dyskinesia. In a series of 30 patients with a variety of choreiform movement disorders, including Huntington's disease, L-dopa-induced dyskinesia, and tardive dyskinesia, we have been unable to dernonstrate consistent cholinergic responsiveness. Intravenous physostigmine reduced chorea in Huntington's disease in only two of 12 patients, whereas choreiform movements were abolished or suppressed in five of seven patients with L-dopa-induced dyskinesias.Keywords
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