‘Magnetic bandages’ for targeted delivery of therapeutic agents
- 8 September 2006
- journal article
- Published by IOP Publishing in Journal of Physics: Condensed Matter
- Vol. 18 (38) , S2877-S2891
- https://doi.org/10.1088/0953-8984/18/38/s23
Abstract
We investigate planar periodically magnetized structures for use in targeting or controlling the delivery of therapeutic agents attached to small magnetic particles, and derive simple analytic expressions for the relevant magnetostatic forces. We show that improved particle trapping or confinement characteristics are possible relative to those that can be obtained with more conventional (i.e. uniformly magnetized) structures. These improvements include forces that are larger at close range (for equivalent magnetization densities) and that are both unidirectional and uniform over arbitrarily large areas parallel to the magnet surface. Expressions for the magnetostatic forces exerted on point-like magnetic particles in the vicinity of long rods (with circular and ellipsoidal cross sections) uniformly magnetized perpendicular to their axes are summarized in an appendix.Keywords
This publication has 13 references indexed in Scilit:
- Mathematical modelling of magnetically targeted drug deliveryJournal of Magnetism and Magnetic Materials, 2005
- Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particlesJournal of Magnetism and Magnetic Materials, 2005
- Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatmentJournal of Magnetism and Magnetic Materials, 2005
- Magnetically modulated therapeutic systemsInternational Journal of Pharmaceutics, 2004
- Applications of magnetic nanoparticles in biomedicineJournal of Physics D: Applied Physics, 2003
- Design of permanent multipole magnets with oriented rare earth cobalt materialPublished by Elsevier ,2002
- Clinical Applications of Magnetic Drug TargetingJournal of Surgical Research, 2001
- Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapyJournal of Magnetism and Magnetic Materials, 1999
- Magnetic targeting of microspheres in blood flowMicrovascular Research, 1984
- One-sided fluxes -- A magnetic curiosity?IEEE Transactions on Magnetics, 1973