Mazindol in the treatment of narcolepsy

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Abstract
Human subjects (34) with the narcoleptic syndrome were treated with mazindol 3-8 mg daily for 1 yr. Treatment caused a sustained improvement in narcolepsy, but had no effect on cataplexy or sleep paralysis. The response to mazindol was excellent in 6 subjects, good in 14, moderate in 12 and poor in 2. No cardiovascular effects, hematological toxicity, tolerance or dependence occurred. Mazindol 6 mg had the same effect on narcolepsy as d-amphetamine 50 mg, but caused less side effects.

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