Relationship of the Viruses of Vesicular Stomatitis and of Equine Encephalomyelitis

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Abstract
After comparison by intracerebral inoculation of guinea pigs, white mice and 2 spp. of monkeys; pad inoculation, of guinea pigs; inoculations into mice; and a study of immunological reactions and other properties, the authors conclude that the 2 viruses are similar in many but not all biological properties, and since the horse is the natural host for both, it is suggested that they may be generically related. However, inasmuch as cross-immunization does not occur, it follows that they are not identical. Just as there are at least 3 types of foot-and-mouth disease and 2 of vesicular stomatitis viruses, each immunologi-cally distinct, the absence of cross-immunity does not exclude the possibility of a generic relationship.

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