Acceptor proteins in rat androgenic tissue chromatin.
- 1 June 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (6) , 1954-1958
- https://doi.org/10.1073/pnas.73.6.1954
Abstract
Fractionation of chromatin [rat prostate, testis, liver and pancreas] into urea-soluble chromosomal nonhistone proteins (UP), histones (MP) and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5.alpha.-dihydrotestosterone (17.beta.-hydroxy-5.alpha.-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin its hormone-receptor binding capacity.Keywords
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