GABA transporters (GAT-1) in Alzheimer's disease

15 February 1999

journal article
Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section

Vol. 106 (11-12) , 1141-1149
https://doi.org/10.1007/s007020050230

Abstract

The presynaptically located γ-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [³H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [³H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.

Keywords

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