Antibodies to IGA in Pregnancy and in Recipient of Rho(D) Immune Globulin (Human)
- 1 November 1972
- journal article
- Published by Wiley in Transfusion
- Vol. 12 (6) , 394-399
- https://doi.org/10.1111/j.1537-2995.1972.tb00032.x
Abstract
A group of 192 Rh‐negative postpartum women were studied to determine the role of pregnancy and of Rho (D) immune globulin (human) in the production of anti‐IgA antibodies. One hundred and thirty‐two women received 1–2 ml of Rho (D) immune globulin soon after delivery, and 57 women receiving no Rho (D) immune globulin served as controls. Both groups were reinvestigated at three to nine months postpartum for the presence of anti‐IgA. The incidence of anti‐IgA antibodies was similar in the control group and in the group receiving Rho (D) immune globulin. The prevalence of anti‐IgA antibodies of 24 per cent in pregnancy is significant, compared to a prevalence of 2 per cent in healthy male donors.Keywords
Funding Information
- U.S. Public Health Service (AM‐14514)
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