COMPARISON OF THE DEVELOPMENT OF RESISTANT STRAINS OF TYPE 1 HERPES SIMPLEX VIRUS TO IN VITRO ANTIVIRAL ACTIVITY OF 5-IODO-2- DEOXYURIDINE OR RIBAVIRIN.
- 1 May 1977
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 284 (1 Third Co) , 233-238
- https://doi.org/10.1111/j.1749-6632.1977.tb21955.x
Abstract
Exposure of HSV/1 to low concentrations of ribavirin during 4--5 passages does not produce ribavirin-resistant virus. IDU resistance was developed by HSV/1 while it was being passed simultaneously. This resistance was seen to develop in both KB and Vero cells. The IDU-resistant virus is also resistant to ribavirin in KB cells.Keywords
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