Influence of Dietary Lipid on the Metabolism of Hexobarbital by the Isolated, Perfused Rat Liver
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 21 (1) , 64-67
- https://doi.org/10.1159/000137417
Abstract
Isolated livers from rats fed a diet containing corn oil (10% W/W) perfused with a blood-free, modified Krebs-Henseleit solution cleared hexobarbital at a rate significantly faster than livers from rats fed a similar diet devoid of corn oil. The half-lives of hexobarbital in these experiments were 22.4 ± 1.8 min for livers from rats fed corn oil and 30.0 ± 1.2 min for those from rats fed the fat-free diet. This represented a metabolic rate of 54 μg hexobarbital/g liver/min in fat-fed animals and 36 μg hexobarbital/g liver/min in those fed a fat-free diet.Keywords
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