Halothane‐Induced Liver Damage: An Analysis of the Material Reported to the Swedish Adverse Drug Reaction Committee, 1966–1973
- 1 March 1976
- journal article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 20 (1) , 40-46
- https://doi.org/10.1111/j.1399-6576.1976.tb05007.x
Abstract
An analysis of 94 reports to the Swedish Adverse Drug Reaction Committee of patients with liver injury after surgery and halothane anaesthesia (including 13 fatal cases) has not been able to reveal any other factors responsible for the liver injury than the halothane administration. Eighty‐two per cent of the total material and 12 out of 13 fatal cases had had multiple exposures. Our results suggest that the liver injury becomes more severe after repeated exposures; maximum serum bilirubin and SGOT values are higher after an increasing number of halothane exposures.Keywords
This publication has 4 references indexed in Scilit:
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- Jaundice after Repeated Exposure to Halothane: An Analysis of Reports to the Committee on Safety of MedicinesBMJ, 1974
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